Spatiotemporal mechanisms of eIF5A1/2-mediated metastasis in triple-negative breast cancer

Transforming Growth Factor Beta (TGFbeta) is a secreted protein and the first member of the TGFbeta superfamily of ligands to be described. However, the molecular mechanisms that govern TGFbeta's ability to switch between its paradoxical growth suppressing and epithelial-mesenchymal transition (EMT) promoting functions remain to be fully elucidated. Since TGFbeta elicits pleiotropic functions during normal...