Jheem Medh
Professor

Brief Biography

I completed my undergraduate degree in Chemistry and Biochemistry, and my M.Sc. in Biochemistry, from the University of Bombay. My Ph.D. in Biochemistry (1986-1990) is from the University of Texas Medical Branch in Galveston. My post-doctoral training was at the University of California in San Diego (1991-1993). I continued research at the University of Iowa before joining CSUN in 2001 as a tenure-track faculty member.

I am now retired and am no longer accepting research students.

My research at CSUN was focused on understanding cellular events that lead to metabolic disorders such as diabetes, obesity, and atherosclerosis. We demonstrated a direct relationship between the level of lipoprotein lipase (LPL) expression and insulin resistance in rat muscle cells. Cells with a knock-down of the LPL gene were more responsive to insulin and show greater glucose uptake, glucose oxidation and glycogen synthesis compared to wild-type cells.
In another project, we showed that mice with macrophage-specific overexpression of the LPL gene (huLPL+/+) developed larger atherogenic lesions compared to huLPL-/- mice. Silencing the LPL gene in THP-1 macrophages improved cholesterol efflux due to increased expression of the cholesterol transporter ABCA1, providing a mechanism for the atherogenic role of macrophage LPL.
A list my publications can be found at:
http://www.ncbi.nlm.nih.gov/sites/myncbi/jheem.medh.1/bibliography/9636445/public/?sort=date&direction=descending

Research 

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