Analysis of EGFR-dependent sleep in C. elegans

Disordered sleep impairs cognitive performance, and chronic sleep loss is associated with increased risk of cardiometabolic diseases including obesity and hypertension. Despite the fundamental importance of sleep, its function remains controversial and the molecular mechanisms by which it is executed are only beginning to be elucidated. Sleep is recognized to be regulated by conserved genetic mechanisms, and in the past decade the sleep field has exp...

CAREER: FIRE lab investigation of stress-induced sleep in C. elegans

Despite the fundamental importance of sleep, the cellular function of sleep remains controversial. Sleep is recognized to be conserved across species, and in recent years sleep research has been extended to model organisms that provide powerful tools for genetic analysis. This project focuses on identification of genes and signaling pathways that control sleep behavior using the roundworm C. elegans as model organism. The princi...