Spatiotemporal mechanisms of eIF5A1/2-mediated metastasis in triple-negative breast cancer

Transforming Growth Factor Beta (TGFbeta) is a secreted protein and the first member of the TGFbeta superfamily of ligands to be described. However, the molecular mechanisms that govern TGFbeta's ability to switch between its paradoxical growth suppressing and epithelial-mesenchymal transition (EMT) promoting functions remain to be fully elucidated. Since TGFbeta elicits pleiotropic functions during normal...

Cellular and Molecular Mechanisms of PEAK1-Mediated TGFbeta Signaling and Function

Transforming growth factor beta (TGFbeta) has well-established roles in regulating both normal physiological and pathophysiological processes. The multi-faceted effects of TGFbeta are commonly mediated by both canonical Smad2/3 signaling and a variety of non-canonical signaling pathways. While TGFbeta signaling is essential during embryogenesis and tissue homeostasis, its dysregulation can lead to aberrant fibrosis...

Fibrillin-1 and TGFB2 Abnormality Models POAG Pathogenesis and Treatment

Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. This project?s long-term goal is to develop more effective clinical therapy through the discovery and improved understanding of glaucoma pathogenesis. We want to learn how to modify underlying disease mechanisms to an extent that it significantly alters the natural course of disease, preserves vision, and positively impacts patients? l...