RUI: Unraveling the physiological roles of multidrug efflux pumps in bacteria

Overview. Bacteria are intrinsically equipped with a variety of multidrug efflux pumps. These pumps first gained interest because of their ability to expel antibiotics out of cells, thus conferring resistance to multiple antibiotics. However, recent findings have shown that these pumps have a broad impact on gene expression, metabolism, and bacterial motility, among other physiological processes. A mechanistic under...

Role of multiple antibiotic efflux pumps in the removal of cellular metabolites

Bacteria resistant to multiple antibiotics are one of the major challenges to public health worldwide. Bacterial pumps capable of effluxing multiple antibiotics out of cells are major contributors to this problem, and are also involved in virulence. These pumps are present in all bacteria, and are well conserved in many cases. AcrAB>TolC is the main multidrug efflux in Escherichia)coli and many other important patho...