Metabolic targeting of cancer cells via the methylglyoxal detoxification systems

Cancer cells from a variety of tumor types rely on the metabolic process of glycolysis even in the presence of oxygen. The cancer cell needs glucose for the production of energy and the biosynthesis of nucleic acids, amino acids and lipids needed to sustain high levels of cellular proliferation. The rate of aerobic glycolysis in cancer cells is elevated to a much higher degree compared to normal tissue, such that who...

Metabolic targeting of cancer cells via the glyoxalase detoxification system

Cancer metabolism is an area of research that is experiencing a renaissance as new models and methodologies add to Otto Warburg?s pioneering work from nearly 80 years ago. Warburg found that tumors are often ?addicted? to glucose even when grown in the presence of oxygen. Aerobic glycolysis or the Warburg effect continues to be used in the clinic today to image a variety of tumor types using 2-deoxy-2-[18F]-D-glucose p...