Intramolecular cycloaddition reactions of electron-rich alkynes: new methods for the synthesis of optically active building blocks for organic synthesis

Ynol ethers and alkynamines are functional groups that possess significant potential in organic chemistry for the formation of carbon-carbon bonds. Due to their linear geometry, electron-rich alkynes are relatively unhindered to approach by functional groups present in the same or different molecules, and can prospectively form up to three new b...

RUI: Functionalized bis (morindone-C, O-glycosides) for the molecular recognition of DNA in the major groove

Investigators in the field of molecular recognition study the non-covalent interactions between two (or more) molecules with the aim of understanding the driving forces behind these associations. With this information in hand, it is possible to develop a set of rules for the design of molecules (ligands) capable of specific binding interactions with other target molecules (receptors). DNA...